基础医学与临床2011，Vol.31Issue(11)：1289-1292,4.
X-盒结合蛋白1的生理及病理生理学作用
Physiological and pathophysiological functions of X-box binding protein
张霞丽 1万福生1
作者信息
- 1. 南昌大学医学院生物化学与分子生物学教研室,江西南昌330006
- 折叠
摘要
Abstract
X-box binding protein 1 (XBP-1) is an important component of unfolded protein response. XBP-1 has two splicing variants designated spliced XBP-1 (XBP-1S) and unspliced XBP-1 (XBP-1U) respectively. During endoplasmic reticulum stress, XBP-1 is induced by ATF6 and spliced by IRE1, thereby generated functional XBP-1S and activating unfolded protein response. As an important transcription factor, XBP-1 plays important roles in the regulation of cell growth and differentiation and is involved in the genesis and development of human diseases.关键词
X-盒结合蛋白1/转录调控/内质网应激Key words
XBP-1/ transcriptional regulation/ ERS分类
医药卫生引用本文复制引用
张霞丽,万福生..X-盒结合蛋白1的生理及病理生理学作用[J].基础医学与临床,2011,31(11):1289-1292,4.
