基础医学与临床2011，Vol.31Issue(11)：1200-1204,5.
阿托伐他汀减轻缺血复合冷应激诱导的大鼠心肌损伤
Effect of atorvastatin on myocardial injury in rats following co-stress of myocardial ischemia and cold
摘要
Abstract
Objective To investigate the role of atorvastatin in myocardium of rats following co-stress of myocardial ischemia and cold stress, and the relative mechanism. Methods Co-stress model was developed by ligation of left coronary artery combined with cold stress of 4 ℃ ,8 h/d for 4 consecutive days. Rats were gavaged with atorvastatin 20 mg/( kg · D) for 3 days before MI was induced. Cardiac function was assessed by echocardiography; myocardial infarct size was determined by TTC staining; p-PI3K, p-GSK3B, Bim and Caspase-3 expression in myocardium was determined by western blotting. Results It was demonstrated that co-exposure to myocardial ischemia and cold stress could significantly deteriorate the cardiac function and increase the infarct size (P <0. 01) , and this was attenuated by atorvastatin with increased expression of p-PI3K, p-GSK3B, and Bim, Caspase3 downregulating(P < 0. 01). Conclusion Atorvastatin may attenuate cardiac injury induced by co-stress of myocardial ischemia and cold stress through activating PI3K/Akt/GSK3B pathway and decreasing expression of Bim.关键词
心肌梗死/冷刺激/阿托伐他汀/BimKey words
myocardial infarction/cold stress/atorvastatin/Bim分类
医药卫生引用本文复制引用
黄茶花,谢遥,黄晓,鲍晓明,王耀晟,程晓曙..阿托伐他汀减轻缺血复合冷应激诱导的大鼠心肌损伤[J].基础医学与临床,2011,31(11):1200-1204,5.基金项目
“十一五”国家科技支撑计划项目(2008BAI68B02) （2008BAI68B02）
