解放军医学院学报2011，Vol.32Issue(11)：1155-1157,3.DOI:11-3275/R.20110627.0831.001
中链甘油三酯对C57BL/6J小鼠棕色脂肪组织的影响
Effect of medium chain triglycerides on brown adipose tissue in C57BL/6J mice
张永 1刘英华 1张新胜 1于晓明 1徐庆 1王觐 1宫雪 1杨雪艳 1薛长勇1
作者信息
摘要
Abstract
Objective To study the effect of medium chain triglycerides(MCT) on brown adipose tissue(BAT) in C57BL/6J mice. Methods Thirty male C57BL/6J mice at the age 4-5 weeks, enrolled in this study, were randomly divided into MCT group, LCT group and control group( 10 in each group). Animals in the first two groups were fed with high fat diet containing MCT or LCT, and those in control group were fed with standard chow for 15 weeks. Body weight, subscapular brown fat mass, diet consumption, and uncoupled protein-1(UCP1) expression in BAT of different groups were observed. Results After 15 weeks, the body weight and body fat mass were significantly lower in MCT group than in LCT group(P<0.05). No significant difference was noted in diet consumption between MCT and LCT groups(R>0.05). The brown fat mass and UCP1 expression were significantly higher in MCT group than in LCT group(P<0.05). Conclusion MCT can inhibit the increase of body mass and accumulation of body fat due to high fat diet by increasing brown fat mass, UCP1 expression and heat production in brown fat tissue.关键词
中链甘油三酯/肥胖/棕色脂肪组织/解偶联蛋白Key words
medium-chain triglycerides/obese/brown adipose tissue/uncoupled protein分类
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张永,刘英华,张新胜,于晓明,徐庆,王觐,宫雪,杨雪艳,薛长勇..中链甘油三酯对C57BL/6J小鼠棕色脂肪组织的影响[J].解放军医学院学报,2011,32(11):1155-1157,3.
