中国药房2011，Vol.22Issue(41)：3883-3886,4.
盐酸双苯氟嗪单层芯渗透泵控释片的研制
Research and Preparation of Dipfluzine Hydrochloride Monolithic Osmotic Pump Controlled-release Tablets
李立 1白靖 1曹德英1
作者信息
- 1. 河北医科大学药学院,石家庄市050017
- 折叠
摘要
Abstract
OBJECTIVE: To prepare Dipfluzine hydrochloride (DH) monolithic osmotic pump controlled-release tablets and to investigate the effects of factors on drug release in vitro. METHODS: DH monolithic osmotic pump controlled-release tablets were prepared and coated with cellulose acetate. Similarity factor was used to study the influence of types of cosolvent, the amount of porosity-making agent PEG 6000, and thickness of coating on drug membrane release to determine and validate the optimal method. RESULTS: Above factors were all main influential factors of drug release (f2<60), the adjuvant solution were tartaric acid and suc-cinic acid (65:130), the composition of coating membrane were cellulose acetate and PEG 6000 (10:1), the amount of PEG 6000 was 10%, the weight of coating membrane was 3%. 3 batches of prepared tablets released steadily in 12 h, showing zero-order release characteristics (r=0.996 3). CONCLUSION: DH monolithic osmotic pump controlled-release tablets are stable in preparation technology and meet the requirements of controlled-release tablets.关键词
盐酸双苯氟嗪/单层芯渗透泵控释片/相似因子法/制备/处方Key words
Dipfluzine hydrochloride/ Monolithic osmotic pump controlled-release tablets/ Similarity factor/ Preparation/ For mulation分类
医药卫生引用本文复制引用
李立,白靖,曹德英..盐酸双苯氟嗪单层芯渗透泵控释片的研制[J].中国药房,2011,22(41):3883-3886,4.
