四川中医2011，Vol.29Issue(11)：14-16,3.
灵杞黄斑颗粒对光损伤大鼠视网膜c-fos、caspase-3及bcl-xL表达的影响
Effect of Lingqi Huangban Granule on c-fos, caspase-3 and bcl-xL Expression in Light-induced Retinal Damage of Rat
摘要
Abstract
Objective: To investigate the effect of lingqi Huangban Granule (LQHB) on apoptosis - associated c-fos, caspase-3and bcl-xL expression in light-induced retinal damage of rat. Methods: Sprague-Dawley (SD) rats were randomly divided into three groups: normal control group, light damage with vehicle group and light damage with LQHB group, whose retinal light impairment waa induced by exposure to white fluorescent constant light forS hours. At 2 ~5h, 5h, after Id and 3d light exposure, the mRNA and protein expression of c-fos, caspase-3, bcl-xL were observed by RT-PCR and western bolt methods. Results: The mRNA and protein expression of c-fos and caspase-3 was down regulated. The mRNA and protein expression of bcl-xL was up regulated. Conclusions: LQHB could regulate the expression of apoptosis-associated gene in light-induced retinal damage of rat.关键词
灵杞黄斑颗粒/光损伤/c-fos/caspase-3/bcl-xLKey words
Lingqi Huangban/Granule Light-induced/retinal damage c-fos caspase-3 bcl-xL分类
医药卫生引用本文复制引用
宋毅,宫媛媛,吴星伟..灵杞黄斑颗粒对光损伤大鼠视网膜c-fos、caspase-3及bcl-xL表达的影响[J].四川中医,2011,29(11):14-16,3.基金项目
上海市科学技术委员会资助项目(NO:05dz22322) （NO:05dz22322）
