中国药房2011，Vol.22Issue(41)：3857-3859,3.
基于遗传算法的威布尔溶出曲线参数估算方法研究
Estimation of Weibull Dissolution Curve Parameters Based on Genetic Algorithm
摘要
Abstract
OBJECTIVE: To estimate the Weibull dissolution curve parameters on the basis of the superiority of Genetic Algorithm, that is of strong searching ability. METHODS: According to the dissolution data of raddeanin A in Tongmai pill, Genetic Algorithm Optimization Toolbox of Matlab software was used to estimate the Weibull curve parameters, and also compared with the Nonlinear Least Squares Method. RESULTS: There was no significant difference of Weibull dissolution curve parameters between Genetic Algorithm and Nonlinear Least Squares Method (P>0.05), but the root mean square error of calibration of Genetic Algorithm was smaller than that of Nonlinear Least Squares Method. CONCLUSION: Genetic Algorithm is suitable to estimate the Weibull dissolution curve parameters.关键词
遗传算法/威布尔溶出曲线参数/非线性最小二乘法Key words
Genetic Algorithm/ Weibull dissolution curve parameters/ Nonlinear Least Squares Method分类
医药卫生引用本文复制引用
陈天朝,赵新红,康冰亚..基于遗传算法的威布尔溶出曲线参数估算方法研究[J].中国药房,2011,22(41):3857-3859,3.基金项目
河南省教育厅2009年度自然科学研究计划项目(2009A36003) （2009A36003）
河南省2010年科技发展计划(102102310185) （102102310185）
