中国药房2011，Vol.22Issue(41)：3868-3869,2.
N-乙酰半胱氨酸对糖尿病模型小鼠氧化应激的影响研究
Effects of N-acetyI-L-cysteine on Oxidative Stress in Diabetic Mice
秦淑兰 1金绣春 2赖晓阳1
作者信息
- 1. 南昌大学第二附属医院内分泌科,南昌市330006
- 2. 江西贵溪市人民医院内一科,贵溪市335400
- 折叠
摘要
Abstract
OBJECTIVE: To explore the effect of N-acetyl-L-cysteine (NAC) on oxidative stress in diabetic mice. METHODS: Mice were given Streptozotocin (STZ) intraperitoneally to establish diabetic model. After modeling 8 weeks, diabetic mice were randomly divided into non-treatment group and NAC treatment group (200 mg·kg-1·d-1) with each group of 6 mice. Two groups were given relevant medicine intraperitoneally once a day for 4 weeks. Body weight and blood glucose of mice before and after medication and the level of lipid peroxidation marker (8-isoprostane) in urine was determined after medication, compared with normal control group. RESULTS: Compared with normal control group, body weight of mice in non-treatment group and NAC treatment group decreased significantly before and after treatment, while the level of blood glucose increased significantly (P<0.001). There was no significant difference between two groups. Compared with non-treatment group, the level of 8-Isoprostane in urine in NAC treatment groups decreased significantly (P<0.01). There was no significant difference between normal control group and NAC treatment group. CONCLUSION: NAC could effectively attenuate the oxidative stress in diabetic mice.关键词
糖尿病/小鼠/N-乙酰半胱氨酸/氧化应激Key words
Diabetes/ Mice/ JV-acetyl-L-cysteine/ Oxidative stress分类
医药卫生引用本文复制引用
秦淑兰,金绣春,赖晓阳..N-乙酰半胱氨酸对糖尿病模型小鼠氧化应激的影响研究[J].中国药房,2011,22(41):3868-3869,2.
