中国药房2011，Vol.22Issue(41)：3873-3875,3.
丙戊酸镁对小鼠急性脑缺血再灌注损伤的预防作用研究
Preventive Effect of Magnesium Valprote against Acute Cerebral Ischemia-reperfusion Injury in Mice
李祖成 1王垣芳 1亓树莹 2李淑翠1
作者信息
- 1. 滨州医学院,烟台市 264003
- 2. 山东烟台市海港医院,烟台市264003
- 折叠
摘要
Abstract
OBJECTIVE: To investigate the preventive effect of magnesium valprote on acute cerebral ischemia-reperfusion (IR) injury in mice and its mechanism. METHODS: Mice were randomly divided into sham operation group, model group, and magnesium valprote high-dose and low-dose groups (0.04, 0.02 mg-g-1) with 10 mice in each group. Those groups were administrated with relevant drugs intragastrically twice a day for 14 days. 1 hour after the last administration, in the latter three groups acute cerebral IR injury models were established. After modeling, cerebral index, MDA content, activities of SOD and GSH-Px in cerebral tissue were determined, and the cell morphology in cerebral cortex and hippocampus CA1 were observed. RESULTS: Compared with model group, neural injury relieved in magnesium valprote high-dose and low-dose groups, cerebral index and MDA content decreased significantly, but activities of GSH-Px increased significantly (P<0.01 or P<0.05). Furthermore, SOD activity increased significantly in magnesium valprote high-dose group (P<0.01). CONCLUSION: Magnesium valprote has preventive effect against acute cerebral IR injury, which is associated with anti-oxidation effect.关键词
丙戊酸镁/急性脑缺血再灌注/小鼠/抗氧化/预防作用Key words
Magnesium valprote/ Acute cerebral ischemia-reperfusion/ Mice/ Anti-oxidation/ Preventive effect分类
医药卫生引用本文复制引用
李祖成,王垣芳,亓树莹,李淑翠..丙戊酸镁对小鼠急性脑缺血再灌注损伤的预防作用研究[J].中国药房,2011,22(41):3873-3875,3.
