中国肿瘤生物治疗杂志2011，Vol.18Issue(4)：430-433,4.DOI:10.3872/j.issn.1007-385X.2011.04.017
急性白血病患者外周血Treg细胞与Th17细胞的相关性
Relationship between Treg and Th17 cells in peripheral blood of acute leukemia patients
摘要
Abstract
Objective: To observe the proportions of CD3+ CD4+ TIL-17 + helper T cells (Thl7 cells) and CD4 + TCD25 + Foxp3 + regulatory T cells (Tregs) in the peripheral blood of acute leukemia patients and the changes of related cytokines (including IL-17, TGF-p, IL-6) , and to analyze their relationship. Methods: The ratios of Treg and Thl7 cells in peripheral CD4+ T cells were examined by flow cytometry. The serum levels of IL-17, TGF-p and IL-6 were measured by ELISA. Results: The ratio of Thl7 cells in CD4+T cells was (1.39 ±0. 24)% , which was significantly higher than that in the control group ([ 0. 26 ± 0. 11 ] % , P ＜ 0. 05 ) ; the ratio of Treg cells in CD4+ T cells was (11. 58 ± 2. 17) % , which was significantly higher than that in the control group ([ 2.47 ± 0. 72 ] % , P ＜ 0. 05); and Treg cells were positively related with Th17 cells. The serum levels of TGF-β, IL-6, and IL-17 in acute leukemia patients were (26.06 ±2. 43) , (14.66 ±2.47), and (18.63 ±2.38) pg/ml, respectively, which were significantly higher than those in the control group ([13.41 ± 1.92] ,[1.44 ±0.29], and [10.34 ±1.71] pg/ml, P＜0.05). Conclusion: The ratios of Treg and Th17 cells are increased in the peripheral blood of acute leukemia patients, and they are positively correlated with each other. The serum levels of TGF-β, IL-6, and IL-17 are also elevated, which may affect the balance between Treg cells and Th17 cells.关键词
急性白血病/调节性T细胞/Th17细胞/TGF-β/IL-6/IL-17Key words
acute leukemia/ regulatory T cell (Treg) / Thl7 cell/TGF-β/IL-6/IL-17分类
医药卫生引用本文复制引用
黄建霞,张连生,易良才,曾鹏云,吴重阳,白俊..急性白血病患者外周血Treg细胞与Th17细胞的相关性[J].中国肿瘤生物治疗杂志,2011,18(4):430-433,4.基金项目
甘肃省科技支撑计划资助项目(No.0804NKCA115). （No.0804NKCA115）
