实用临床医药杂志2011，Vol.15Issue(17)：102-104,3.
替吉奥胶囊联合多西他赛治疗晚期食管癌临床疗效观察
Clinical observation of S-1 capsule combined with Docetaxel on patients with advanced esophageal cancer
葛伯建 1高湘湘 1顾寄树 1谭清和1
作者信息
- 1. 江苏省南通市肿瘤医院内科,江苏南通,226001
- 折叠
摘要
Abstract
Objective To observe the therapeutic effect and drug tolerance of S- 1 capsule combined with Docetaxel on patients with advanced esophageal cancer. Methods Thirty - one pa tients with advanced esophageal cancer were treated with S - 1 capsule 80 mg/m2, twice daily for 14 days and Docetaxel 25 mg/m2 intravenously 1 hour on day 1 and 8. The chemotherapy was repeated every 21 days. The therapeutic effect, adverse reactions and follow- up condition were observed af ter treatment. Results Two cases showed complete remission (CR), 11 cases partial remission (PR), 8 cases stable disease (SD), 10 cases progressive disease (PD). Response rate (CR+ PR) was 41.9%, illness control rate (CR + PR + SD) was 67.7 %. The major adverse events were grade Ⅰ to Ⅲ myelosuppression, hand - foot syndrome and diarrhea. Some patients had the damage of liver function. The median time to progress (mTTP) was 7.4 months. The median 1 - year survival rate was 74.2%. Conclusion The combination of S-1 capsule and Docetaxel is an effective and well - tolerated regimen for the patients with advanced esophageal cancer.关键词
食管癌/替吉奥/多西他赛/化疗Key words
esophageal cancer/ S-l/ Docetaxel/ chemotherapy分类
医药卫生引用本文复制引用
葛伯建,高湘湘,顾寄树,谭清和..替吉奥胶囊联合多西他赛治疗晚期食管癌临床疗效观察[J].实用临床医药杂志,2011,15(17):102-104,3.
