王俊霞 1孙海翔 1王玢 1侯晓妮 1朱静静 1胡娅莉1
作者信息
- 1. 南京大学医学院附属鼓楼医院生殖医学中心,南京210008
- 折叠
摘要
Abstract
Objective: To evaluate the predictive value of age, AFC and bFSH on ovarian reserve function in women undergoing in vitro fertilization and embryo transfer. Methods: 6387 long protocol IVF/ICSI-ET cycles from Jan. 2003 to Dec. 2009 were analyzed retrospectively by ROC curve. Results: (1 )The areas under ROC curve( AUC)of age, AFC and bFSH for predicting the poor response rate were 0. 69 ( AUC1) ,0. 86 ( AUC2), and 0. 70 ( AUC3 ) respectively , which were all larger than the areas under the diagnosis reference line(P<0. 05). AUC2 was significantly larger than AUC1 and AUC3 ( Zl2 = 9. 43 , Z23 = 8. 21, P<0. 05 ), and there was no significant difference between AUC1 and AUC3(Z]3 =0. 35,P>0. 05). (2) The AUC of age, AFC and bFSH for predicting the clinical pregnancy rate were 0. 57(AUC4) ,0. 55 (AUC5) ,and 0. 53 (AUC6) respectively, which were all larger than those under the diagnosis reference line(P<0.05). AUC4 was significantly larger than AUC5 and AUC6(Z45 =2. 21 ,Zm = 3.98,P<0. 05 ), and there was no significant difference between AUC5 and AUC6 (Z56 = 1.77,P>0.05). (3)AUC1,AUC2 and AUC3 were separately larger than AUC4, AUC5, and AUC6(Z,4 = 7.18,Z25=24.75,Z36 = 9. 31,P<0. 05). Conclusions: Age,bFSH and AFC are all valuable in prediction of ovarian reserve function, whereas AFC achieves the better value in predicting ovarian response than age and bFSH. Age is better at predicting the clinical pregnancy than AFC and bFSH. Age, AFC and bFSH are better at predicting the poor response to gona-dotrophin stimulation than the chance of pregnancy.关键词
年龄/窦卵泡数/基础卵泡刺激素/卵巢储备功能/受精,体外/胚胎移植Key words
Female age/ Antral follicle count/ Basal FSH/ Ovarian reserve/ Fertilization in vitro/Embryo transfer分类
医药卫生
