中华医学杂志（英文版）2011，Vol.124Issue(22)：3635-3640,6.DOI:10.3760/cma.j.issn.0366-6999.2011.22.007
Progression of diabetic retinopathy: the Beijing Eye Study
Progression of diabetic retinopathy: the Beijing Eye Study
TU Ying 1XU Liang 2WEI Wen-bin 3WANG Shuang 4WANG Ya-xing 2Jost B Jonas5
作者信息
- 1. Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University
- 2. Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730,China
- 3. Department of Ophthalmology, Jiangyin People's Hospital,Dongnan University, Jiangyin, Jiangsu 214400, China
- 4. Beijing Institute of Ophthalmology , Beijing Tongren Hospital, Capital Medical University
- 5. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
- 折叠
摘要
Abstract
Background Diabetic retinopathy (DR) has emerged as a leading cause of visual impairment and blindness in the working-aged population worldwide.This study aimed to assess frequency and associated factors of progression of DR in subjects with known diabetes in a population-based setting.Methods The Beijing Eye Study is a population based study performed in Greater Beijing in 2001 and 2006.The present investigation included all subjects with known diabetes mellitus in 2001,who participated in the follow-up examination in 2006.Fundus photographs were assessed.Results The study included 170 subjects; 51 (30％) subjects showed signs of DR in 2001 and were re-examined in 2006,36 (21.2％) subjects (18 subjects with DR present at baseline,18 subjects with newly diagnosed DR in 2006)showed a progression of DR during follow-up.Progression of DR was associated with rural region (odds ratio (OR):5.43,P＝0.001) and self-reported arterial hypertension (OR:3.85,P＝0.023).In the non-progressive subgroup,presence of DR was associated with different levels of education (＜middle school,middle school,college or higher,OR:0.30,P＝0.023),treatment modes of diabetes mellitus (OR:10.24,P＝0.003) and cataract surgery (OR:9.14,P＝0.007).Conclusions In a population-based setting in Greater Beijing,progression of DR occurred in 35％ of subjects with pre-existing DR and overall in 21％ of subjects with known diabetes within a 5-year period.Progression of DR was significantly associated with rural region and self-reported arterial hypertension.In the stable subjects,presence of DR was significantly associated with poor educational level,insulin treatment of diabetes and cataract surgery.关键词
progression/diabetic retinopathy/Beijing Eye StudyKey words
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TU Ying,XU Liang,WEI Wen-bin,WANG Shuang,WANG Ya-xing,Jost B Jonas..Progression of diabetic retinopathy: the Beijing Eye Study[J].中华医学杂志（英文版）,2011,124(22):3635-3640,6.
