首页|期刊导航|中华医学杂志（英文版）|Genotype and allele frequencies of heme oxygenase-1 promoter region in a Greek cohort
中华医学杂志（英文版）2011，Vol.124Issue(20)：3408-3411,4.DOI:10.3760/cma.j.issn.0366-6999.2011.20.036
Genotype and allele frequencies of heme oxygenase-1 promoter region in a Greek cohort
Genotype and allele frequencies of heme oxygenase-1 promoter region in a Greek cohort
摘要
Abstract
Background Heme oxygenase-1 (HO-1) is an enzyme,which catabolizes heme into carbon monoxide,biliverdin and free iron.The induction of this enzyme is an important cytoprotective mechanism,which occurs as an adaptive and beneficial response to a wide variety of oxidant stimuli.HO-1 inducibility is mainly modulated by a (GT)n polymorphism in the promoter region,and has been shown that short (S) repeats are associated with greater up-regulation of HO-1,compared with long (L) repeats.Methods In the present study,250 healthy Greek individuals have been screened in order to estimate the frequencies of (GT)n alleles in the HO-1 gene.Results Nineteen different alleles,ranging from 17 to 39 repeats,with (GT)23 and (GT)30 being the most common ones,were identified.Conclusion The possible role of this polymorphism in disease states is discussed.关键词
heme oxygenase-1/microsatellite polymorphism/promoter/Greek populationKey words
heme oxygenase-1/microsatellite polymorphism/promoter/Greek population引用本文复制引用
Eleni P. Katana,Lemonia G. Skoura,Zacharias G Scouras,Michail A. Daniilidis..Genotype and allele frequencies of heme oxygenase-1 promoter region in a Greek cohort[J].中华医学杂志（英文版）,2011,124(20):3408-3411,4.基金项目
This research study was partially supported by a grant from the State Scholarships Foundation of Greece,in the field of Medical Biology and the Hippokration,General Hospital of Thessaloniki. （）
