生物医学工程研究2011，Vol.30Issue(3)：159-163,5.
纳米羟基磷灰石/羧甲基壳聚糖-海藻酸钠复合骨水泥的生物相容性与体内降解研究
Research on Biocompatibility and In Vivo Degradation of Nono- hydroxyapatite/Carboxymethychitosan- Sodium Alginate Bone Cement Composite Material
摘要
Abstract
To evaluate the biocompatibility and in vivo degradation of Nano hydroxyapatite /Carboxymethychitosan - sodium alginate bone cement composite material and provide some date for the clinical application. According to the standard for the biological evaluation of the material devices (GB/T16886), several tests including hemolysis test, pyrogen test, acute systemic toxicity test, acute cellular toxicity test, in vivo degradable test were performed to evaluate biocompatibility and safety of the material. The material had no hemolytic reaction, no acute systemic toxicity, no acute cellular toxicity, and no pyrogen reaction. The results demonstrated that the implanted material had only a mild inflammatory reaction during the early days , which subsided gradually; meanwhile the implanted material were degraded gradually. The nanohydroxyapatite/Carboxymethychitosan- sodium alginate bone cement composite material has good biocompatibility and great biological safety though the surgical application still re quires a future clinical research.关键词
纳米羟基磷灰石/羧甲基壳聚糖/海藻酸钠/生物相容性Key words
Nano - hydroxyapatite/ Carboxymethychitosan/ Sodium alginate/ Biocompatibility分类
医药卫生引用本文复制引用
肖海军,薛锋,何志敏,金粉勤,沈玉春..纳米羟基磷灰石/羧甲基壳聚糖-海藻酸钠复合骨水泥的生物相容性与体内降解研究[J].生物医学工程研究,2011,30(3):159-163,5.基金项目
上海市自然科学基金资助项目(09ZR1426100) （09ZR1426100）
