生物医学工程研究2011，Vol.30Issue(3)：174-176,187,4.
柠檬黄对雄性小鼠生殖细胞的影响
Toxic Effects of Tartrazine on Reproductive Cells in Male Mice
摘要
Abstract
To investigate the effects of tartrazine on reproductive cells in male mice.In order to research the tenacity effects of tartrazine on procreation cells of male mice, male adult mice were randomly divided into a control group, a tartrazine low - dosage group (0.25g/kg), a tartrazine mid - dosage group (0.5g/kg) and a tartrazine high - dosage group (lg/kg). All mice were exposed to tartrazine by gastic gavage for S days consecutively. The micronuclei rates of testicle cells, the spermatozoon monstrosity rates and testicle tissue were tested to explore the toxicity of reproductive cells.The results indicated that compared with the control group, micronucleus frequencies and spermatozoon monstrosity rates of male mice increased significantly in high - dosage groups ( P < 0.05) and there was no significant difference among low - dosage, medium-dosage groups and the control group (P>0.05). There were no distinct histological changes in low- dosage and mid- dosage groups with comparison to those in the control group, however, in high - dosage group, lots of exutive spermatogenic cells were observed in the luminaof seminiferous tubule and the number of sperm cells were decreased. Since the spermatozoon monstrosity rates and micronucleus frequencies of male mice are raised by tartrazine, tartrazine can result in mutation to a certain extent.关键词
柠檬黄/生殖细胞/微核/精子畸形/雄性小鼠Key words
Tartrazine/ Reproductive cells/ Micronucleus/ Spermatozoon monstrosity/ Male mice分类
医药卫生引用本文复制引用
蒋利刚,程东,韩晓英,孟小倩,景来东,刘树真..柠檬黄对雄性小鼠生殖细胞的影响[J].生物医学工程研究,2011,30(3):174-176,187,4.基金项目
山东省教育厅资助项目.00(J07YG02) （J07YG02）
山东省优秀中青年科学家科研奖励基金资助项目(2007BS02014 （）
2008BS02016) （）
