同济大学学报（医学版）2011，Vol.32Issue(4)：10-13,4.DOI:10.3969/j.issn.1008-0392.2011.04.003
丙氨酰谷氨酰胺对猪体外循环后肠黏膜屏障的保护作用
N(2)-L-Alanyle-L-Glutamine protects intestinal mucosa barrier in pigs undergoing cardiopulmonary bypass
摘要
Abstract
Objective To investigate the effects of N(2)-L-Alanyle-L-Glutamine(Gln) on the intestinal mucosa barrier during cardiopulmonary bypass (CPB). Methods Sixteen Shanghai white pigs undergoing CPB were randomly divided into two groups: the control group and the experimental group(n =8 in each). Gin at 0.4 g/kg was administrated to the pigs in experimental group at beginning and 60 min after CPB. Plasma endotoxin, IL-6 and TNF-a levels were measured before operation, at the end of CPB and 1 h after operation. Results Plasma endotoxin, IL-6 and TNF-a levels during CPB and at the end of operation were significantly higher than those of pre-operation in both groups. However, the plasma level of endotoxin, IL-6, TNF-a in experimental group were much lower than those in control group at the postoperative time points. The pathological examination also revealed that the damage of intestinal mucosa was attenuated in experimental group. Conclusion N(2) -L-Alanyle-L-Glutamine can protect the intestinal mucosa barrier in pigs undergoing CPB.关键词
体外循环/丙氨酰谷氨酰胺/内毒素Key words
cardiopulmonary bypass/ N(2)-L-Alanyle-L-Glutamine/ endotoxin分类
医药卫生引用本文复制引用
张治国,洪暄,孙梅,叶亮,范慧敏,刘中民..丙氨酰谷氨酰胺对猪体外循环后肠黏膜屏障的保护作用[J].同济大学学报（医学版）,2011,32(4):10-13,4.基金项目
上海市浦东新区科技局项目(PKJ2008-33) （PKJ2008-33）
浦东新区卫生系统重点学科群建设项目(PKzxkq2010-01) （PKzxkq2010-01）
