摘要
Abstract
Objective To understand the situation of hepatitis B infection in patients with hepatocirrhosis, and to explore the relationships among hepatitis B virus markers( HBVM ), HBV - DNA and pre - SI antigen( pre - SI - Ag )in order to provide evidence for clinical antiviral therapy of hepatocirrhosis. Methods Serum HBVM, HBV - DNA and pre - SI - Ag in 451 patients with hepatocirrhosis were detected and analyzed. Results Among these patients,the infection rate of HBV was 85. 4%( 385/451 )and the positive rate of the HBsAg was 71. 4%( 322/451 ). Among the patients with positive HBsAg,the infection patterns containing negative HBeAg were the most, which accounted for 75. 5%( 243/322 ). The positive rates of HBV - DNA and pre - SI - Ag were 82. 3%( 265/ 322 )and 63. 4%( 204/322 ),respectively. Among the patterns of HBsAg( + ),HBeAg( + )and anti - HBc( + ),the positive rate of HBV - DNA and pre - SI - Ag were much higher, and were 98. 7% and 78. 4% , respectively. The positive rate of HBV - DNA was higher than that of pre - SI - Ag(^- =29. 20,P <0. 05 ). Conclusion The hepatocirrhosis is closely related to HBV infection in which negative HBeAg is predominant. Detection of HBV - DNA and pre - SI - Ag in blood serum of patients with hepatocirrhosis can reflect the degree of HBV replication and activeness in those patients, which makes up for the deficiency of HBVM in the hepatocirrhosis detection.关键词
肝硬化/HBV血清标志物/HBV-DNA/前S1抗原Key words
hepatocirrhosis/ HBV serum markers/ HBV - DNA/ pre - SI antigen分类
医药卫生
