浙江医学2011，Vol.33Issue(11)：1572-1574,1579,4.
PPAR-γ2基因外显子B的P12A变异与2型糖尿病相关性研究
Relationship between pro12Ala polymorphisms in PPAR-γ2 gene and type 2 diabetes of littoral Han population in Zhejiang Province
摘要
Abstract
Objective To investigate the association of P12A variant in peroxisome proliferators activated receptor- γ 2 (PPAR-γ 2) gene with type2 diabetes. Methods The genotypes of P12A variants in PPAR-γ 2 were determined by gene biochip assay in 308 subjects of littoral Han population of Zhejiang Province, including 126 patients with type 2 diabetes mellitus, and 182 healthy subjects. The clinical characteristics including height, weight, waist circumference, hip circumference, fast plasma glucose (FPG), 2h plasma glucose after glucose loading (2hPG) and fast insulin (FIN) were measured and their relationship with genotype of P12A variants was analyzed. Results The allele frequencies in the case and controlgroup were 87.3%, 89.6% for P; 12.7%, 10.4% for Arespectively. The genotype frequencies were 74.6%, 79.1% for PP; 25.4%, 20.9% for PA+AA The P12A variant of PPAR- γ 2 was not significantly associated with type 2 diabetes (P >0.05 ). The frequencies of the Ala 12 carrier in diabetic patients was associated with increased waist circumference (P<0.05). Conclusion The data show that P12A variant polymorphism of PPAR-γ 2 in littoral Han population of Zhejiang is not associated with type 2 diabetes, but it might be a risk factor for metabolic disorder in diabetic patients.关键词
过氧化物酶体增殖物激活受体-γ2/基因/2型糖尿病/多态性Key words
Peroxisome proliferators activated receptor-γ 2 gene/Type 2 diabetes/Polymorphism引用本文复制引用
陈恩福,饶高峰,林海洋,吴金友,薛诚,王焰兵..PPAR-γ2基因外显子B的P12A变异与2型糖尿病相关性研究[J].浙江医学,2011,33(11):1572-1574,1579,4.基金项目
温岭市科委资助项目(2008WLCA0046) （2008WLCA0046）
