武警医学2011，Vol.22Issue(12)：1019-1023,5.
光比浊法评价老年心血管疾病患者阿司匹林抵抗的现患率及相关危险因素
Prevalence of and risk factors for aspirin resistance by light transmittance aggregometry in elderly patients with cardiovascular disease
摘要
Abstract
Objective To evaluate the prevalence of and risk factors for aspirin resistance in elderly patients with cardiovascular disease(CVD) by light transmittance aggregometry (LTA). Methods 454 patients( age, 73. 91 ±8. 12 years) with CVD receiving daily aspirin therapy ( ^75 mg) over one month were recruited. Results By LTA, 38 (8. 4% ) elderly patients were found to be resistant to aspirin therapy; 166 (36. 5% ) patients were semi - responders; 204(44. 9% ) patients were nonsensitive. In the multiva-riate logistic regression analysis, the administration of angiotensin - converting enzyme inhibitors or angiotensin receptor blockers (ACEIs/ARBs) (0^=0.638, 95% Cl: 0.414-0.983, P = 0. 042) , and nitrates (OR=Q.57Q, 95% Cl: 0.367-0.884, P = 0. 012) was a significant protective factor for aspirin non - sensitivity. Conclusions The prevalence of aspirin resistance in elderly patients with CVD is considerably high. The administration of ACEIs/ARBs and nitrates is a protective factor for aspirin non - sensitivity.关键词
光比浊法/阿司匹林抵抗/老年患者/心血管疾病/危险因素Key words
aspirin resistance/ elderly patients/ light transmittance aggregometry/ cardiovascular disease/ risk factors分类
临床医学引用本文复制引用
曹剑,刘霖,范利,胡国梁,胡亦新,李晓利,石海燕..光比浊法评价老年心血管疾病患者阿司匹林抵抗的现患率及相关危险因素[J].武警医学,2011,22(12):1019-1023,5.基金项目
军队十一五重点保健课题(07BJZ01),国家科技部支撑计划课题 (2009BAI86B04) （07BJZ01）
