武警医学2011，Vol.22Issue(12)：1067-1069,1072,4.
丙泊酚对肝移植患者肾功能的保护作用
Protective effect of propofol on renal function during liver transplantation
谢兰云 1陈晖 2雷志礼 2韩曙君 2宁新宇2
作者信息
- 1. 221000,徐州医学院江苏省麻醉学重点实验室
- 2. 100039,北京,武警总医院麻醉科
- 折叠
摘要
Abstract
Objective To investigate the effect of propofol on renal function during orthotopic liver transplantation (OLT). Methods Forty ASA IH - IV patients aged 30 to 55, weighing 50 ~75 kg and undergoing OLT for late stage liver cirrhosis were randomly divided into two groups (re =20 each) ; control group and propofol group. Anesthesia was induced with midazolam, sufentanil , etomidate in control group and propofol in propofol group. Tracheal intubation was facilitated with vecuronium. The patients were mechanically ventilated. Anesthesia was maintained with isoflurane, continuous infusion of cisatracurium and intermittent iv sufentanil in control group but with isoflurane, continuous infusion of propofol and cisatracurium , intermittent iv sufentanil in propofol group. The two groups maintained standard MAP-.BIS. Venous blood samples were collected after admission into the operating room (Tl) , at the beginning of the anhepatic phase ( T2) , at the end of the anhepatic phase ( T3 ) , 1 h and 2 h into the neohepatic phase ( T4, T5 ) and closed abdominal(T6) for determination of plasma concentrations of creatinine( Cr) -.blood urea( Urea) and (S2 ~ microglobin( |S2 -MG). Results Compared with Tl, Cr at T3-,T4-,T5-,T6 increased in both groups. Urea increased at T5-.T6 in control group but decreased at T2-.T3 and increased at T5-.T6 in propofol group. P2 - MG decreased at T2-.T3, increased at T5-.T6 in control group but decreased at T2 in propofol group . Cr at T5-.T6, Urea at T4-.T5-.T6 and (S2 ~ MG at T6 in propofol group were all lower than in control group. Conclusions Propofol has protective effect on renal function during liver transplantation .关键词
丙泊酚/肝移植/肌酐/血尿素/β2-微球蛋白Key words
propofol/ Liver transplantation/ creatinine/ blood urea/ fi2 - microglobin分类
医药卫生引用本文复制引用
谢兰云,陈晖,雷志礼,韩曙君,宁新宇..丙泊酚对肝移植患者肾功能的保护作用[J].武警医学,2011,22(12):1067-1069,1072,4.
