重庆医学2011，Vol.40Issue(34)：3447-3449,后插2,4.DOI:10.3969/j.issn.1671-8348.2011.34.006
27例T淋巴母细胞白血病/淋巴瘤的病理及临床分析
Pathological and clinical analysis of 27 cases of T lymphoblastic leukemia/ lymphoma
摘要
Abstract
Objective To explore the pathological and clinical characteristic of T lymphoblastic leukemia(T-LBL) /lymphoma. Methods Tumor tissue from 27 patients with confirmed diagnosis of T-LBL were subjected to histopathological and immunohisto-chemical analysis,and their clinical symptom features, diagnosis, treatment, curative effects and survival conditions were analyzed. Results The most common very early signs and symptoms were lymphadenectasis(81. 5% ), followed by fatigue (63. 0%) and cough (48. 1%). There were 70.4% of patients with mediastinal mass,29. 6% with multiple serous cavity effusion, 70. 4 % with bone marrow invasion and 3. 7% with extensive invasion of skin and oral mucosa. 25 cases(92. 6%) were in phase Ⅲ - Ⅳ,and 2 ca-ses(7. 4%) in phaseⅡ. Positive rate of terminal deoxynucleotidyl transferase (TdT) ,CD3 and CD99 were 100.0% ,81. 5% and 85. 2% , respectively,and different degrees of CD4 3,CD2 ,CD4 ,CD7 and CD8 expression were demonstrated. After an average of 5 courses of treatment,the median survival time of patients was 11 months,and the survival time of patients with multiple serous cavity effusion was all less than 6 months. More than 2 years survival had been found in 3 cases of hematopoietic stem cell transplantation and one case of high-dose chemotherapy. 3 patients with tumor invasion in central nervous system and one patient with skin and oral mucosa extensive invasion survived only 1. 5 months. Conclusion Hematopoietic stem cell transplantation is an effective approach to treat T-LBL,a highly malignant lymphoma with very poor prognosis,and prolong survival.关键词
淋巴瘤,T细胞/病理状态,体征和症状/免疫组织化学/造血干细胞移植/预后Key words
lymphoma, T-cell/ pathological conditions, signs and symptoms/ immunohistochemistry/ hematopoietic stem cell transplantation/ prognosis引用本文复制引用
田小波,符刚,陈洁平,朱江..27例T淋巴母细胞白血病/淋巴瘤的病理及临床分析[J].重庆医学,2011,40(34):3447-3449,后插2,4.基金项目
第三军医大学第一附属医院临床创新基金资助项目(SWH2006B007). （SWH2006B007）
