安徽农业科学2011，Vol.39Issue(24)：14545-14547,3.
反义寡核苷酸介导的miRNA沉默研究
Study of miRNA Silencing Mediated by Antisense Oiigonucleotide
夏新 1张小敏 2宋鹏飞 3王爽3
作者信息
- 1. 重庆大学生物工程学院基因工程研究中心,重庆400030
- 2. 西南医院感染科,重庆400030
- 3. 深圳华大基因研究院,广东深圳518083
- 折叠
摘要
Abstract
MicroRNAs ( miRNAs) were noncoding BNAs approximately 22 nucleotides in length that played a key role in the regulation of important biological processes, including cellular development, differentiation, and apoptosis. miRNA silencing wasn't only an important tool used for researching biological function of miRNA, but also enable the diagnosises and treatments targeting for miRNA. A variety of chemically modified antisense oligonucleotides and the corresponding proposed system had been used for miRNA research.关键词
miRNA沉默:反义寡核苷酸/化学修饰Key words
miRNA silencing/ Antisense oligonucleotides/ Chemical modification分类
农业科技引用本文复制引用
夏新,张小敏,宋鹏飞,王爽..反义寡核苷酸介导的miRNA沉默研究[J].安徽农业科学,2011,39(24):14545-14547,3.
