华中师范大学学报（自然科学版）2011，Vol.45Issue(2)：266-271,6.
氧化胁迫在TRPV1受体去敏后的活化以及甲醛唤起的痛觉效应中的作用
Oxidative stress plays a role in activating desensitized TRPV1 receptor and formaldehyde-induced hyperalgesia
摘要
Abstract
Through the modified mice hind paw injection test, firstly, we've observed differences between activation of TRPV1 by formaldehyde and capsaicin, which indicate an indirect activation of TRPV1 by formaldehyde. Then, the function of reactive oxygen species in overriding TRPV1 desensitization is checked. After that, we've proved acute oxidative toxicity of formaldehyde and effectiveness of antioxidants protection from pain in modified formaldehyde test. In conclusion, oxidative stress gives a positive force to the sensitization and activation of TRPV1, and this rule does also apply into the mechanism of TRPV1 activation by formaldehyde.关键词
TRPV1/甲醛/痛觉过敏/氧化胁迫Key words
TRPV1/ formaldehyde/ hyperalgesia/ oxidative stress引用本文复制引用
罗清,杨尚悦,吴旗,陈闪,杨旭..氧化胁迫在TRPV1受体去敏后的活化以及甲醛唤起的痛觉效应中的作用[J].华中师范大学学报（自然科学版）,2011,45(2):266-271,6.基金项目
教育部大学生创新性实验计划项目(1010511005). （1010511005）
