华东师范大学学报（自然科学版）Issue(4)：94-103,123,11.DOI:10.3969/j.issn.1000-5641.2011.04.011
αCaMKII过量表达增强小鼠岛叶皮层兴奋性突触传递
αCaMKII overexpressions enhance excitatory synaptic transmission in insular cortex of mice
摘要
Abstract
The experiment was designed to study basic electrophysiological characteristics and basal synaptic transmission of insular pyramidal cells in αCaMKII forebrain overexpression mice by patch clamping. The basic electrophysiological results showed that there were no significant differences in the resting membrane potential, action potential and I-V curve of pyramidal cells in insular cortex between wild type and transgenic mice. No significant difference was measured in the frequency of sEPSCs and mEPSCs. However, compared to the wild type mice, transgenic mice exhibited augmented amplitude of sEPSCs and mEPSCs. There was also no significant difference in PPF curve. The results suggested that forebrain specific overexpression of aCaMKII did not change the basic electrophysiological characteristics and presynaptic transmitter release in insular cortex. The influence of αCaMKII overexpression on the amplitude of EPSCs may be mediated by postsynaptic receptors.关键词
αCaMKII/ 岛叶皮层/ 兴奋性突触后电流Key words
αCaMKII/ Insular cortex/EPSCs分类
生物科学引用本文复制引用
刘汝清,段燕红,曹晓华..αCaMKII过量表达增强小鼠岛叶皮层兴奋性突触传递[J].华东师范大学学报（自然科学版）,2011,(4):94-103,123,11.基金项目
国家自然科学基金(31070993) （31070993）
