华东师范大学学报（自然科学版）Issue(4)：115-123,9.DOI:10.3969/j.issn.1000-5641.2011.04.013
CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关
Meta-analysis of CYP1A1 polymorphisms and lung cancer risk among smokers
摘要
Abstract
All of the publications were eligible from Medline and Pubmed databases and the information about relationship between CYP1A1 Ile462Val and Msp1 polymorphisms and lung cancer risk among smokers was summarized. Meta-analysis was performed using RevMan 4. 2. 29 case-control studies were available. For Ile462Val, meta-analysis revealed that the risk of lung cancer among smokers with Val/Val and Ile/Val genotypes was 1. 29 times of those with Ile/Ile genotype (P<0. 05) by the random effects model. There was no significant correlation between Mspl and lung cancer among smokers or non-smokers. These results suggest that CYP1 A1 Ile462Val polymorphism is related to the susceptibility of lung cancer among smokers.关键词
肺癌/CYP1A1基因/ 多态性/meta分析Key words
lung cancer/CYP1A1/polymorphisms/meta-analysis分类
临床医学引用本文复制引用
蔡燕燕,谭晓明,郑红霞,顾海英,詹晓莹,吴奇涵..CYP1A1基因Ile462Val多态位点在吸烟人群中与肺癌易感性显著相关[J].华东师范大学学报（自然科学版）,2011,(4):115-123,9.基金项目
上海市自然基金(10ZR1408700) （10ZR1408700）
