吉林大学学报（理学版）2011，Vol.49Issue(5)：957-963,7.
壳聚糖羟丁基衍生物的制备及性质
Preparation and Properties of Hydroxybutyl Chitosan
摘要
Abstract
Water-soluble hydroxybutyl chitosan ( HBCS ) was prepared by the reaction of chitosan ( CS ) with 1,2-butane oxidation in an alkali solution. The structure of HBCS was characterized by FT-IR and solid state 13C NMR, and the results prove that the hydroxybutyl has been successfully connected to chitosan molecular chain. The degree of hydroxybutyl substitution estimated by means of elemental ananlysis is 1.2. Besides, HBCS exhibited good water-solubility and could dissolve in aqueous solutions in a broader pH range. In comparison with CS, HBCS shows a poorer thermostability. This is because the modified reaction destroys the crystalline region of chitosan. Antibacterial activities of CS and the modified derivative were explored by turbidity method. The results show that HBCS exhibits antibacterial activity against E. Coli and S. Aureus, and with the increase of concentration, the antibacterial effect enhances obviously. It was found that the antimicrobial activity of HBCS is weaker than that of CS under the same mass concentrations.关键词
壳聚糖/羟丁基壳聚糖/结构表征/理化性质Key words
chitosan/ hydroxybutyl chitosan/ structure characterization/ physiochemical property分类
生物科学引用本文复制引用
李晶晶,党奇峰,程晓杰,陈西广..壳聚糖羟丁基衍生物的制备及性质[J].吉林大学学报（理学版）,2011,49(5):957-963,7.基金项目
国家自然科学基金(批准号:40876065). （批准号:40876065）
