摘要
Abstract
Objective To explore the effects of nicorandil on cardiac function and blood glucose in patients with chronic heart failure (CHF). Methods 64 patients with CHF were randomly divided into control group and treatment group. Both 2 groups received conventional therapy for heart failure. And the treatment group was treated with nicorandil additionally (5 mg once, 3 times a day for 12 weeks). 6-minute walk text (6MWT), plasma N-terminal-pro brain natriuretic peptide (NT-proBNP), fasting plasma glucose (FPG), postprandial 2 hours plasma glucose (P2hPG) and glycated hemoglobin Ale (GHbAlc) were measured before and after treatment. Results After the treatment, the 6-minute walking distance and the plasma NT-proBNP levels of both groups were improved significantly (P<0.01), especially in treatment group (P<0.05); the level of FPG, P2hPG and GHbAlc were not significantly different between 2 groups. Conclusion Nicorandil can effectively improve the exercise tolerance of the patients with CHF, reduce the Plasma NT-proBNP level, but it has no effect on the level of blood glucose.关键词
尼可地尔/心力衰竭/6分钟步行实验/脑钠肽/运动耐量/血糖Key words
nicorandil/ chronic heart failure/ 6-Minute Walk Test/ brain natriuretic peptide/ exercise tolerance/ blood glucose分类
医药卫生
