同位素2011，Vol.24Issue(3)：172-176,5.
99Tcm-MAVGG-Glu的肿瘤定位性能
Tumor Locating Property of 99Tcm-MAVGG-glucose
摘要
Abstract
To develop 99Tm labeled glucose derivatives for imaging tumor with SPECT, β-N-mercaptoacetyl-Val-Gly-Gly-glucose (MAVGG-Glu) was labeled with 99Tcm. The labelled compound was injected into the mice bearing S180 tumors, and biodistribution was measured at 3 h and 5 h postinjection. The biodistribution of 18F-2-fluoro-desoxy glucose (18F-FDG) at 5 h postinjection was also studied for comparison. The results showed that 99Tcm labeling yield was greater than 90%. The tumor uptakes at 3 h and 5 h postinjection were 1.46±0.41 and 1. 28±0. 24%ID/g, respectively. The T/NTs were greater than 1.8 for tumor over all other normal tissues excepted for kidney and liver at 5 h postinjection. T/NT of tumor to blood, tumor to muscle and tumor to brain were 4. 41, 4. 00 and 8. 53, respec-tively. Tumor was visualized at 3 h postinjection, and the contrast became slightly sharper with time lasted. The results suggested the potential utility of 99Tcm-MAVGG-Glu as a suitable tumor imaging agent. Compared with 99F-FDG,99Tcm-MAVGG-Glu had lower tumor uptake and T/NTs for most tissues. But its T/NTs for tumor to muscle, heart, spleen and brain, especially for tumor to brain, were higher, which indicated that 99Tcm-MAVGG-Glu may have advantages in imaging brain tumor and the tumor near brain.关键词
99Tcm/MAVGG-Glu/肿瘤/定位性能Key words
99Tcm/ MAVGG-Glu/ tumor/ locating property分类
医药卫生引用本文复制引用
张春丽,齐传民,付占立,赵云岭,郭凤琴,孙彭利,王荣福..99Tcm-MAVGG-Glu的肿瘤定位性能[J].同位素,2011,24(3):172-176,5.基金项目
国家自然科学基金资助项目(20171008,20371009) （20171008,20371009）
