山西大学学报（自然科学版）2011，Vol.34Issue(3)：449-452,4.
3,6-位不对称二取代咔唑衍生物的合成研究
Study on the Synthesis of 3,6-Disubstituted Asymmetric Carbazole Derivatives
摘要
Abstract
With carbazole as mainly synthetic material,two novel compounds of 3,6-disubstituted asymmetric carbazole derivatives were prepared by a serious of reactions, such as N- alkylation,Friedel-Crafts acyla-tion, nitration and Friedel-Crafts alkylation. The factors affected the reactions,such as the mol ratio of substrates, the quantity of catalyst,reaction temperature and reaction time were explored and the optimum reaction conditions are as follows; (1) For the reaction of Friedel-Crafts acylation,with the mol ratio 1 : 1. 2 ':1. 5 of N-ethylcarbazole,anhydrous aluminum chloride and acetyl chloride,82% yield of the product was obtained at room temperature for 4 h;(2) For the reaction of nitration, with the mol ratio 1:1. 15 of the N-ethylcarbazole and 65% nitric,89% yield of the object product was obtained at 5 - 10 °C for 2 h;(3) For the reaction of Friedel-Crafts alkylation, with the mol ratio 1 : 1. 5 : 1. 5 of 3-acetyl-N-ethylcarbazol,anhydrous zinc chloride and tert. -butyl chloride,64% yield of the product was obtained at room temperature for 12 h. The structures of object products were characterized by FTIR、1H NMR、13C NMR and MS.关键词
不对称咔唑衍生物/傅克反应/硝化反应Key words
asymmetric carbazole derivatives/Friedel-Crafts reaction/nitration分类
化学化工引用本文复制引用
赵三虎,刘瑞琴,亢丽娜,葛海霞,赵明根..3,6-位不对称二取代咔唑衍生物的合成研究[J].山西大学学报（自然科学版）,2011,34(3):449-452,4.基金项目
山西省高校科技开发资助项目(2010124) （2010124）
山西省大学生创新性试验资助项目([2008]32) （[2008]32）
