儿科药学杂志2011，Vol.17Issue(6)：10-13,4.
104例儿童系统性红斑狼疮肾炎临床及病理分析
The Clinical and Pathological Analysis of 104 Cases of Children's Lupus Nephritis
杨琴 1王墨 1李秋 1赵晓东 1唐雪梅1
作者信息
- 1. 重庆医科大学附属儿童医院,重庆,400014
- 折叠
摘要
Abstract
Objective: The purpose was to understand the relationship between clinical and pathological characteristics of children s lupus nephritis ( LN ). Methods; We Collected the clinical and pathological medical records of children with lupus nephritis from January 2000 to April 2010, and performed a retrospective analysis. Results; ( 1 ) Among 104 cases, the male to female ratio was 1:4.2. The peak age of morbidity ranged from 9 to 15 years old. ( 2 ) Together 98 children ( 94. 23% ) with systemic lupus erythematosus ( SLE ) had urinary or renal function abnormalities when first diagnosed. ( 3 ) Forty patients received renal biopsy, 23 cases ( 57. 50% ) were Class IV nephritis, which was the most frequent histopathology, followed by class Ⅱ (22. 50% ) and Ⅴ+Ⅲ ( 7. 50% ). Nephrotic syndrome was the most frequent clinical manifestation, accounting for 30. 00% ( 12 cases ) of all clinical types. There was no significant distinction in the distribution of pathological classifications among various clinical types ( x2 =37. 365, P = 0. 139 ). ( 4 ) SLEDAI score ( disease activity ) was correlated to AI ( activity index ) ( P=0.014), but not correlated to pathological classifications ( F=1. 62, P=0. 212). Conclusions; There is no correlation between pathological classifications and clinical types of children s lupus nephritis. So timely renal biopsy could help patients to get timely treatment and to improve the prognosis.关键词
狼疮肾炎/儿童/临床表现/病理类型Key words
Lupus nephritis/ Children/ Clinical manifestation/ Pathological classification分类
医药卫生引用本文复制引用
杨琴,王墨,李秋,赵晓东,唐雪梅..104例儿童系统性红斑狼疮肾炎临床及病理分析[J].儿科药学杂志,2011,17(6):10-13,4.
