中国动脉硬化杂志2011，Vol.19Issue(11)：919-922,4.
非糖尿病维持性血液透析患者髓过氧化物酶与颈动脉硬化的相关性
Correlation of Myeloperoxidase and Carotid Atherosclerosis in Non-diabetic Patients with Maintenance Hemodialysis
摘要
Abstract
Aim To study possible clinical relationships of myeloperoxidase (MPO) and carotid atherosclerosis in non-diabetic patients with maintenance hemodialysis (MHD). Methods Levels of plasma MPO and serum elastase (ELT) of non-diabetic patients with MHD were determined by ELISA. Carotid intima-media thickness (IMT) , quantity and area of carotid plaque were measured by B-mode ultrasonography. Results There was no significant difference of serum ELT before and after hemodialysis (HD). Plasma MPO was significantly higher after HD than before HD (P < 0. 01). There was positive correlation between age, MPO level before HD and carotid IMT (P < 0. 01). There was no correlation between the levels of plasma MPO after HD and serum ELT or carotid IMT. Conclusions MPO level before HD contributed to carotid atherosclerosis in patients on MHD. In contrast, there was no relation between higher MPO level after HD and carotid atherosclerosis. This finding suggests that increased plasma MPO levels after HD do not reflect increased activation/degranulation of leukocytes and supports the view that the increase in circulating MPO reflects the hep-arin-induced release from the atherosclerotic vascular wall.关键词
维持性血液透析/髓过氧化物酶/颈动脉粥样硬化Key words
Maintenance Hemodialysis/ Myeloperoxidase/ Carotid atherosclerosis分类
医药卫生引用本文复制引用
赵战云,颜炳丽,王春光,李松,郝力海,尹丽丽..非糖尿病维持性血液透析患者髓过氧化物酶与颈动脉硬化的相关性[J].中国动脉硬化杂志,2011,19(11):919-922,4.基金项目
山东省自然科学基金(y2007c114) （y2007c114）
