摘要
Abstract
To date, atherosclerosis has been considered as an inflammatory process triggered by diverse immune cells. The cells involved in innate immunity such as monocytes and macrophages, adaptive immunity such as T cells and B cells, and cytokines secreted by immune cells all participate in the process. However, the cells involved functions differently with some promoting atherosclerosis while others inhibiting it. In human, CD14+ CD16+ was pro-inflammatory, whereas CD14+ CD16- was anti-inflammatory. Thland Thl7 cells have a pro-atherogenic role, while Th2 and CD4+ CD25+ regulatory T cells act oppositely. In recent years, antibodies targeting oxLDL were proven athero-protective in studies. It is no doubt that a further understanding of immunological mechanisms in atherosclerosis will guide effective prevention and therapeutics of this disorder.关键词
动脉粥样硬化/免疫调节/固有免疫/适应性免疫Key words
Atherosclerosis/ Immunological Regulation/ Innate Immunity/ Adaptive Immunity分类
医药卫生
