中国肺癌杂志2011，Vol.14Issue(11)：848-852,5.DOI:10.3779/j.issn.1009-3419.2011.11.03
核心蛋白聚糖decorin在非小细胞肺癌组织中低表达且与组织学类型相关
Decorin Protein is Down-regulated in Non-small Cell Lung Cancer Tissue and Significantly Associated with Histological Type
摘要
Abstract
Background and objective Decorin is a protein component of the extracellular matrix. It has been proven that decorin plaid an important role in matrix assembly. The protein is also capable of suppressing tumor cell growth. The aim of this study is to examine the protein levels of decorin in tissue samples of non-small cell lung cancer (NSCLC) patients and evaluate its potential clinical value. Methods Decorin protein levels in tumor tissues and corresponding normal tissues from 16 cases of lung squamous cell carcinoma (SCC) were determined by Western blot analysis. Fifty-one NSCLC samples, including both tumor and normal lung tissues, were examined by immunohistochemical (IHC) staining. Results Western blot results showed that decorin protein levels in 75.0% (12/16) of the SCC tumor tissues were lower than those of the corresponding normal lung tissues. IHC results showed that positively stained decorin was detected in only 11.8% of the tumor tissues, significantly lower than that observed in normal alveoli tissues (53.1%, P<0.00l). In lung adenocarcinoma (ADC), almost no expression of decorin was observed, in contrast to squamous cell carcinoma (SCC) (P=0.006). Conclusion Decreased levels of decorin in NSCLC tissue samples, particularly ADC cases, indicate that decorin could play a role in lung cancer carcinogenesis.关键词
核心蛋白聚糖/肺肿瘤/低表达Key words
Decorin/ Lung neoplasms/ Down-regulation This study was supported by a grant from the National Science Foundation of China (to Yanning GAO) (No.30930042).分类
医药卫生引用本文复制引用
吴永凯,肖汀,李敏,张莹,高燕宁,孙克林..核心蛋白聚糖decorin在非小细胞肺癌组织中低表达且与组织学类型相关[J].中国肺癌杂志,2011,14(11):848-852,5.基金项目
本研究受国家自然科学基金(No.30930042)项目资助 （No.30930042）
