组织工程与重建外科杂志2011，Vol.7Issue(5)：290-294,5.DOI:10.3969/j.issn.1673-0364.2011.05.014
毛囊干细胞定向分化过程中Wnt信号通路介导的基因调控
Gene Regulation by Wnt Signaling Pathway in the Oriented Differentiation of Hair Follicle Stem Cells
摘要
Abstract
Wnt signaling pathway plays a decisive role in morphological development and oriented differentiation of hair follicle stem cells (HFSCs) with the ability of self-replication and the potential of multiplex differentiation. Investigation of many important proteins involving in Wnt signaling pathway such as Wnt, Frizzled, β-catenin, GSK3β, APC, Axin has been carried out relatively earlier and deeper. While investigation of some downstream effectors especially the transcription factors located in cell nucleus, like Tcf3, Lefl and gene c-myc, cyclinDl regulated by Tcf3 and Lefl is still at the primary phase. This paper reviews gene regulation of oriented differentiation of hair follicle stem cells by Wnt signaling pathway, so as to provide theoretical reference in tissue engineered skin.关键词
毛囊干细胞Wnt信号通路基因调控Key words
Hair follicle stem cells/ Wnt signaling pathway/ Gene regulation分类
生物科学引用本文复制引用
向萌娟..毛囊干细胞定向分化过程中Wnt信号通路介导的基因调控[J].组织工程与重建外科杂志,2011,7(5):290-294,5.基金项目
国家自然科学基金(30772099),北京市自然科学基金(7112111). （30772099）
