中华耳科学杂志2011，Vol.9Issue(3)：323-326,4.
雌激素对小鼠风洞噪声性听力损伤的保护作用
Protection against wind tunnel noise induced hearing damage by estrogen in mice
摘要
Abstract
Objective To investigate potential protective effects of estrogen against hearing damage in mice exposed to wind tunnel noise. Methods Sixty mice were randomly divided into three groups (A, B and C, 20 each) and exposed to wind tunnel noise 8 hours per day for 7 consecutive days. Animals in Group B received intramuscular injection of 0.15 mg estradiol benzoate 30 min before noise exposure, and those in Group C received the same treatment but at 30 min after the exposure. Animals in Group A received no treatment. Auditory brainstem response (ABR) thresholds were obtained before noise exposure, on Days 3 and 7 during the exposure, and on Days 3 and 7 after the exposure. The cochlea was also harvested for scanning electron microscope (SEM) study at each time point. Results ABR thresholds were elevated along with noise exposure in all groups. ABR thresholds showed recovery on Days 3 and 7 post-exposure, but the recovery was greater in Group C than in Groups A and B. SEM examination showed the most severe cochlear damage in Group A, followed by group B, and the least amount of damage in Group C. Conclusion Wind tunnel noise causes cochlear damage with hearing threshold elevation in mice. Estrogen appears to protect against this damage. The protective effects appear to be greater when estrogen is administered as a treatment after noise exposure than when prophylactically given before noise exposure.关键词
风洞噪声/听性脑干反应/雌激素/扫描电镜/保护Key words
Wind tunnel noise/ Auditory brainstem response/ Estrogen/ Scanning electron microscope分类
医药卫生引用本文复制引用
薄少军,孙建芝,王普杰,虞学军,牛聪敏,刘钢,吴玮,韩浩伦,屈昌北,王鸿南,王方园,孟令照,李保卫,王刚..雌激素对小鼠风洞噪声性听力损伤的保护作用[J].中华耳科学杂志,2011,9(3):323-326,4.基金项目
全军十一五医药卫生科技攻关科研项目(项目号:08G059) （项目号:08G059）
