中国临床医学2011，Vol.18Issue(5)：571-574,4.
非小细胞肺癌患者转化生长因子β1水平与机体免疫状态的关系
Relationship between Transforming Growth Factor-Betal and Immunologic Functions in Non-Small Cell Lung Carcinoma Patients
摘要
Abstract
Objective:To investigate the transforming growth factor β1 (TGF-β1) levels and changes of immune function with cancer stage,histological type of cancer in the non-small cell lung carcinoma patients. Methods: A total of 87 hospitalized patients which were histological confirmed non-small cell lung carcinoma (NSCLC), based on the 2009 International Union A-gainst Cancer (UICC) and the International Lung Cancer Research (IASLC) published the seventh edition of the international staging of lung cancer, staging into the group I -IV of patients; also included 42 cases of healthy control subjects. Enzyme-linked immunosorbent assay (ELISA) in peripheral blood fasting TGF-β1 content. Peripheral blood by flow cytometry in CD3+ , CD4+ , CD8+, CD4+ / CDS+ and CD4+ CD25+ cell percentage, and stratified analysis. Results: NSCLC patients with CD3+ , CD4+, CD8+ cells was significantly lower than the controls (P<0. 01); TGF-β1 levels and CD4+ CD256 cells was higher (P<0. 01); NSCLC patients with stage I and II CD3+ , CD4+ , CDS+ cells was higher than in stageIII and IV (P< 0.01); and TGF-β1 levels and CD4+ CD25+ cells was lower than in stage III and IV (P<0.01); but I and II of room, III and IV was no significant difference between (P> 0. 05). Between the different pathological types of TGF-β1 levels and CD3+ , CD4+, CD8+, CD4+ /CD8+ and CD4+ CD25+ cells was not significantly different (P> 0. 05). Conclusions: NSCLC patients with the TGF-β1 and CD4+ CD25+ levels and the patients immune function is a negative correlation, TNM stage later, the immune function, the lower, TGF-01 levels and CD4+ CD25+ cells are higher; but TGF -β1 levels in NSCLC are no difference between different pathological types.关键词
转化生长因子β1/非小细胞肺癌/细胞免疫Key words
Transforming growth factor-β1/Non-small cell lung carcinoma/Cellular immunity分类
医药卫生引用本文复制引用
雷玉洁,黄云超,陈小波,赵光强,杨凯云,陈颖..非小细胞肺癌患者转化生长因子β1水平与机体免疫状态的关系[J].中国临床医学,2011,18(5):571-574,4.基金项目
国家自然科学基金(编号:30872555) （编号:30872555）
云南省科技厅应用基础研究项目(编号:2009ZC116M) （编号:2009ZC116M）
