中国临床医学2011，Vol.18Issue(5)：582-584,3.
血管紧张素Ⅱ-1型受体基因多态性与宁夏汉族原发性高血压病的相关性研究
Study for Association between the Angiogenesis Ⅱ Type I Receptor Gene Polymorphism and Essential Hypertension in Hans of Ningxia
摘要
Abstract
Objective:To investigate the relationship between the polymorphism of angiontensin H type 1 receptor( ATIR) gene A1166C and essential hypertension(EH)in Hans in Ningxia Province, China. Methods: The genomic DNAs were extracted from the peripheral blood of 336 peoples in Ningxia Region. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods were used to detect the A1166C polymorphism of ATIR gene in Hans including 160 patients with EH and 176 normal controls. The frequencies of genotype distribution in EH and normal groups were studied. Results: The distribution genotype frequencies of AA, AC and CC were 93. 1 %, 6. 3% and 0. 6% in hypertension groups, respectively, and those in normal groups were 87. 5 %, 11.4% and 1.1%, respectively, which showed no significant difference( P>0. 05); The allelic frequencies of A and C were 96.3% and 3. 8% respectively in hypertension group, while 93. 2% and 6. 8% in the normal group. The allele frequencies of A/ C were no significant differences to above data in two groups (P>0. 05). Conclusions: It is no significant association found between the A1166C polymorphism of AT1R gene and essential hypertension in Hans of Ningxia.关键词
原发性高血压/血管紧张素Ⅱ-1型受体/基因多态性Key words
Essential hypertension/Angiogenesis II type 1 receptor/Gene polymorphism分类
医药卫生引用本文复制引用
陈丽娜,徐清斌,马萍..血管紧张素Ⅱ-1型受体基因多态性与宁夏汉族原发性高血压病的相关性研究[J].中国临床医学,2011,18(5):582-584,3.基金项目
宁夏自然科学基金(编号:NZ10134) （编号:NZ10134）
