北京中医药大学学报2011，Vol.34Issue(10)：707-710,4.
通腑泻下法干预危重症患者胃肠功能障碍的临床研究
Intervention to gastrointestinal dysfunction and failure with therapy of relaxing bowels and purgation in critical patients
摘要
Abstract
Objective To observe the influence of enema therapy with Chinese medicinal with the actions of relaxing bowels and purgation on gastrointestinal dysfunction and failure ( CIDF) in critical patients and to study the mechanism. Methods All critical patients (n = 74) were randomly divided into the control group and treatment group (each n=37). In the treatment group there were 14 female patients and 23 male ones and the average age was (71. 76 ±11. 93) years old. In the control group there were 17 female patients and 20 male ones and the average age was (72. 76 ± 11.24) years old. The comparison of general materials between two groups showed that the difference was not statistically significant (P < 0.05). The control group was given symptomatic treatment of Western medicine, and the treatment group, retention enema of Chinese medicinal with the actions of relaxing bowels and purgation according to syndrome differentiation besides the same treatment as the control group. A therapeutic course was for 5 days. The changes of diamine oxidase ( DAO), tumor necrosis factor-α ( TNF-α) , interleukin-6 ( IL-6 ) , C-reactive protein ( CRP) and gastrointestinal function were observed in two groups before and after the treatment. Results The levels of DAO, TNF-α, IL-6 and CRP decreased in two groups after the treatment. The comparison of DAO, TNF-α and IL-6 between two groups after the treatment showed that the difference was statistically significant ( P < 0. 05 ) , andcomparison of CRP showed that the difference was not statistically significant (P > 0. 05 ). The improvement of gastrointestinal function in the treatment group was better than that in the control group. Conclusion The enema therapy with Chinese medicinal with the actions of relaxing bowels and purgation can abate GIDF, and the mechanism may be related to the decrease of DAO, TNF-α, IL-6 and CRP levels.关键词
通腑泻下法/灌肠/危重症/胃肠功能障碍Key words
therapy of relaxing bowels and purgation/ retention enema/ critical illness/gastrointestinal dysfunction and failure分类
医药卫生引用本文复制引用
张翔炜,张敏州,翁燕娜,李芳,吴巧媚,张晓璇,韩云..通腑泻下法干预危重症患者胃肠功能障碍的临床研究[J].北京中医药大学学报,2011,34(10):707-710,4.基金项目
广州中医药大学中医药科研创新基金资助项目(No.2007C073) （No.2007C073）
