四川大学学报（医学版）2011，Vol.42Issue(6)：792-796,5.
两株野生鹅膏菌水相多糖的体外抗肿瘤细胞活性研究
Antitumor Activity of Polysaccharides Extracted from Two Wild Amanitas
唐瑗磷 1罗强 1丁文 1丁祥 1杨志荣1
作者信息
- 1. 四川大学生命科学学院资源微生物与生物技术四川省重点实验室,成都610065
- 折叠
摘要
Abstract
Objective To investigate the anti-tumor activity of two wild Amanita strains, and to determine the inhibition ratio of their effective chemical components on tumor cells in vitro. Methods Two wild Amanita strains collected in Sichuan province were identified through morphology and molecular methods. The chemical components from the fruit body of the two strains were extracted with petroleum ether, chloroform, methanol and water. The anti-tumor activity of the extracts were tested on the cancer cells of MGC and Lovo strains. The polysaccharides were isolated with hot water and tested for its anti-tumor activity in vitro. Results The two wild Amanitas were identified as Amanita subjunquillea and Amanita pantherina. The water-soluble extracts from the Amanitas had anti-tumor effect, with polysaccharide as one of the main effective components. The IC50 value of the polysaccharide isolated from Ml was 3. 790 mg/mL for the MGC cells. Conclusion Polysaccharides isolated from the two wild Amanitas have considerable anti-tumor activity against MGC cells in vitro.关键词
鹅膏菌/多糖/抗肿瘤Key words
Amanita/ Polysaccharides/ Antitumor引用本文复制引用
唐瑗磷,罗强,丁文,丁祥,杨志荣..两株野生鹅膏菌水相多糖的体外抗肿瘤细胞活性研究[J].四川大学学报（医学版）,2011,42(6):792-796,5.
