四川大学学报（医学版）2011，Vol.42Issue(6)：802-806,5.
netrin-1蛋白在胃癌组织中的表达与临床病理及预后的关系
netrin-1 Protein Expression in Gastric Cancer and Its Correlation with Clinicopathologic Features and Prognosis
摘要
Abstract
Objective To evaluate the relationship between netrin-1 protein, clinicopathologic features and prognosis in gastric cancer patients. Methods Tissue micro-array and immunohistochemistry were used to detect expression of netrin-1 protein and Ki67. And clinicopathological relevance of netrin-1 protein and Ki67 in gastric cancer were analyzed. Survival rates was evaluated by Kaplan-Meier survival curves. Cox regression analysis was performed to evaluate the possibility of netrin-1 expression as an independent prognostic factor for gastric cancer. Results The positive-expression rate of netrin-1 protein, paracancerous netrin-1 protein and Ki67 in tumor tissue from 67 patients with gastric cancer were 49%, 42% and 60%, respectively, netrin-1 protein expression might be related to depth of invasion, lymth node metastasis and distant metastasis (P<0. 05). But no correlation was observed in sex, tumor diameter and tumor grade (P>0. 05). There was correlation between different degrees of netrin-1 expression and distant metastases (P<0. 05). No correlation was found in the expression of Ki67 and clinicopathological features. The correlation between the expression of netrin-1 and Ki67 was observed (r=0. 359, P<0. 05). Using Kaplan-Meier survival curves and the log-rank test, the correlation of netrin-1 expression, different degrees of netrin-1 expression and survival (P<0. 05) were also observed. But netrin-1 expression was not significantly correlated with the prognosis of gastric cancer (RR=1. 335, 95% CI: 0. 612-2. 914). Conclusion netrin-1 protein may be related with tumorigenesis and tumor progression by affecting proliferation. The detection for netrin-1 may be helpful to evaluate the clinicopathological parameters and survival time. However, it is not an independent prognostic factor for gastric cancer.关键词
胃癌/netrin-1蛋白/增殖/生存期/预后/组织芯片Key words
Gastric carcinoma/ netrin-1 protein/ Proliferation/ Survival time/ Prognosis Tissue micro-array引用本文复制引用
陈金明,王沈华,徐善祥,韩宝三..netrin-1蛋白在胃癌组织中的表达与临床病理及预后的关系[J].四川大学学报（医学版）,2011,42(6):802-806,5.基金项目
浙江省自然基金(批准号Y207543)、浙江省卫生厅医药卫生科技计划项目(项目号H2007B095)和杭州市科技局推进社会发展项目(项目号20061133B16)资助 （批准号Y207543）
