中国临床药理学与治疗学2011，Vol.16Issue(10)：1110-1113,4.
蝙蝠葛碱对离体豚鼠气管平滑肌舒张作用的研究
Relaxation effects of dauricine on isolated tracheal smooth muscles of guinea pigs
摘要
Abstract
To investigate the relaxation effects of Dauricine (Dau) on isolated tracheal smooth muscles of guinea pigs. METHODS: We made tracheal pieces of guinea pigs, and used experimental methods in isolated organs, recorded the relaxation effect of Dau for isolated trachealsmooth muscles of guinea pigs, and also observed the relaxation effect's changes of Dau for isolated tracheal smooth muscles of guinea pigs in different channel and receptor blockers. RESULTS: Dau had a significant relaxing effect on I-solated tracheal smooth muscles of guinea pigs,and the relaxation effect had a significant concentration-dependent between 60 to 120 μmol/L concentrations (P<0. 05). The relaxation of I-solated guinea pig tracheal smooth muscle of nifedipine plus Dau group was weaker than that of Dau group between 80 to 160 μmol/L concentrations (P<0. 05). The relaxation of isolated guinea pig tracheal smooth muscle of propranolol plus Dau group was weaker than that of Dau group between 60 to 120 μmol/L concentrations (P<0. 05), but the relaxation of isolated guinea pig tracheal smooth muscle of propranolol plusDau group was similar compared to Dau group between 120 to 160 μmol/L concentrations(P> 0.05). CONCLUSION: Dau has a significant relaxing effect on isolated tracheal smooth muscles of guinea pigs and it may be related with β2 receptors and inhibiting calcium channel.关键词
蝙蝠葛碱/离体豚鼠气管平滑肌/Ca2+通道/β2受体Key words
Dauricine/ Isolated tracheal smooth muscles of guinea pigs/ Calcium channel/ β2 receptor分类
医药卫生引用本文复制引用
沈柏儒,曾志林,许继德,刘思,许小洋,朱伟思,李茵,简文华..蝙蝠葛碱对离体豚鼠气管平滑肌舒张作用的研究[J].中国临床药理学与治疗学,2011,16(10):1110-1113,4.基金项目
广州市高校科技项目(10A149) （10A149）
广州市科技局课题(2008JIC261) （2008JIC261）
