中国真菌学杂志2011，Vol.6Issue(5)：267-270,4.
舍曲林抗新生隐球菌的体外及动物实验研究
Anti-fungal effect of sertraline on Cryptococcus neoformans in vitro and in vivo
周南 1黄晨 1潘炜华 1廖万清1
作者信息
- 1. 第二军医大学长征医院皮肤病真菌病研究所上海市医学真菌分子生物学重点实验室全军真菌病重点实验室,上海 200003
- 折叠
摘要
Abstract
Objective To assess the efficacy of sertraline on Cryptococcus neoformaru . Methods Fungal-loaded mice were treated by fluconazole ( 10 mg/mL),sertraline (10 mg/mL,20 mg/mL) ,or fluconazole combined with sertraline ( 10 mg/mL & 10 mg/mL,10 rag/mL & 20 mg/mL). Drug-sensitivity tests were performed in vitro with different concentrations of sertraline and fluconazole above. Results Colony numbers of Cryptococcus neoformans decreased in vitro in sertraline group, while much more evidently in combination group of sertraline and fluconazole. In the early stage, both concentrations of sertraline could significantly decrease the colony numbers of Cryptococcus neoformans in lung and brain tissue. However, in the later stage, 10 mg/mL of sertraline showed no anti-fungal effect in brain tissue. Fluconazole was superior to sertraline in lung and brain tissue, and much more efficient in antifungal therapy when combined with sertraline. Conclusions Sertraline is efficient on Cryptococcus neoformans , and may have synergistic action to fluconazole.关键词
新生隐球菌/舍曲林/体外实验/动物实验Key words
Cryptococcus neoformans / sertraline/ in vitro/ in vivo分类
医药卫生引用本文复制引用
周南,黄晨,潘炜华,廖万清..舍曲林抗新生隐球菌的体外及动物实验研究[J].中国真菌学杂志,2011,6(5):267-270,4.
