山东医药2011，Vol.51Issue(39)：4-5,2.
内皮细胞缺氧后miR-210、 miR-92a、miR-126表达及意义
Expression and significance of miR-210, miR-92a, miR-126 in human microcapillary endothelial cells after hypoxia
摘要
Abstract
Objective To investigate the control mechanism of angiogenesis after hypoxia. Methods Human micro-capillary endothelial cells(HMEC)were cultured commonly, and hypoxia model of endothelial cells was prepared with hypoxia incubator( observed group) , the normal cells was taken as control group. The expression of miR-210, miR-92a, miR-126 were detected by real time PCR method. Results It showed a significant up-regulation of miR-210, miR-92a, miR-126 in observed group compared to control group, about 5.19 ±0.99, 3.02 ±0.88 and 3.87 ±0. 83 fold changes respectively. Conclusion Hypoxia can promote the changes of specific microRNA in endothelial cells, which maybe the main control mechanism of angiogenesis after hypoxia.关键词
miR-210/miR-92a/miR-126/人微血管内皮细胞Key words
miR-210/miR-92a/miR-126/human microcapillary endothelial cell分类
医药卫生引用本文复制引用
刘芬,娄远蕾,阮琼芳,谢安,李勇,崔苏萍,汪泱..内皮细胞缺氧后miR-210、 miR-92a、miR-126表达及意义[J].山东医药,2011,51(39):4-5,2.基金项目
国家自然科学基金资助项目(NO.81060059) （NO.81060059）
江西省研究生创新专项资金项目(YC09A019). （YC09A019）
