四川大学学报（医学版）2011，Vol.42Issue(6)：856-860,5.
分化型甲状腺癌患者血清Tg测定值与内源性TgAb浓度的相关性研究
The Correlation between Endogenous TgAb and Experimental Tg Values in Patients with Differentiated Thyroid Carcinomas
摘要
Abstract
Objective To determine the interference of antithyroglobulin (TgAb) on the measurement of serum thyroglobulin (Tg) in patients with differentiated thyroid carcinomas (DTC). Methods The Tg positive serum and TgAb positive serum were taken from the patients with total thyroidectomy and thyroid remnant ablation by radioiodine. The Tg positive serum contained high level of Tg (>10 μg/L) and nondetectable TgAb. The TgAb positive serum contained high level of TgAb (>115 IU/mL) and nondetectable Tg. We incubated a constant amount of Tg with increasing volumes of Tg-free autoantibodies and allowed them to equilibrate at room temperature for 12 hours before measuring Tg and TgAb. The thyroglobulin and TgAb values were determined by the Roche electrode induce chemiluminescent emission system with monoclonal antibody sandwich analysis. The correlation between TgAb and serum Tg values was analysed. Results TgAb led to underestimation of serum Tg values by 15%-50% in 8 patients with DTC. TgAb was correlated with the magnitude of underestimated serum Tg values in 3 patients with DTC, but not in the other 5 patients with DTC. Conclusion TgAb underestimated serum Tg values in a dose-dependent manner in some patients with DTC, but not in others.关键词
分化型甲状腺癌/甲状腺球蛋白/甲状腺球蛋白抗体/干扰Key words
Differentiated thyroid carcinoma/ Thyroglobulin/ Antithyroglobulin/ Interference recovery引用本文复制引用
唐恭顺,胥劲,俞英,潘明志,汪君如,袁丽萍,蒋婷,黄芳,敬春丽..分化型甲状腺癌患者血清Tg测定值与内源性TgAb浓度的相关性研究[J].四川大学学报（医学版）,2011,42(6):856-860,5.基金项目
国家自然科学基金(批准号30970859)资助 （批准号30970859）
