中国药房2011，Vol.22Issue(42)：3992-3994,3.
非TIA非梗死性后循环缺血患者血流动力学变化及盐酸法舒地尔对其的临床疗效
Hemodynamics and Clinical Efficacy of Fasudil Hydrochloride in Patients with Non-TIA and Non-infarction Posterior Circulation Ischemia
魏欣 1邵杰敏 1李丽 2王贺波3
作者信息
- 1. 河北省人民医院药学部,石家庄市050051
- 2. 河北省人民医院功能科,石家庄市050051
- 3. 河北省人民医院神经内科,石家庄市050051
- 折叠
摘要
Abstract
OBJECTIVE: To investigate clinical efficacy and changes of hemodynamics of Fasudil hydrochloride in patients with non-TIA and non-infarction posterior circulation ischemia (PCI). METHODS: 180 patients with non-TIA and non-infarction PCI were randomly divided into fasudil group and control group. Two groups were given Fasudil hydrochloride injection and Bu-flomedil injection for 14 days. Mean blood flow velocity of basilar artery and bilateral vertebral artery were observed using color Doppler. And the clinical efficacies of two groups were compared. RESULTS: After 14 days of treatment, the total effective rate of fasudil group was significantly higher than that of control group (83.33% vs. 67.78%, P<0.05). The mean blood flow velocity of basilar artery and bilateral vertebral artery were significantly increased in two groups (P<0.01 or P<0.05), and the mean blood flow velocity of fasudil group were markedly increased as compared with control group (P<0.05). CONCLUSION: The mean blood flow velocity of vertebrobasilar system is decreased in some patients with non-TIA and non-infarction PCI. The microvascular vasospasm may be one of causes of disease. Fasudil hydrochloride is effective and safe in relieving clinical symptom of some patients with non-TIA and non-infarction PCI.关键词
后循环缺血/血流动力学/法舒地尔/临床用药Key words
Posterior circulation ischemia/ Hemodynamics/ Fasudil/ Clinical medication分类
医药卫生引用本文复制引用
魏欣,邵杰敏,李丽,王贺波..非TIA非梗死性后循环缺血患者血流动力学变化及盐酸法舒地尔对其的临床疗效[J].中国药房,2011,22(42):3992-3994,3.
