中国中医药信息杂志2011，Vol.18Issue(11)：39-40,43,3.DOI:10.3969/j.issn.1005-5304.2011.11.015
菊苣提取物对雌性鹌鹑高尿酸血症模型胰岛素抵抗和雌二醇、三磷酸甘油醛脱氢酶的影响
Effect of Cichorii Extract on Insulin Resistance and E2, GAPDH Level of Female Quail Hyperuricemia Model
摘要
Abstract
Objective To discuss the mechanism of Cichorii extract in decreasing uric acid regarding insulin resistance (IR) and E2, GAPDH as studying object. Methods Quails were randomly divided into 5 groups by weight: control group, model group, positive contral group (20 mg/kg benzbromarone) and Cichorii extract large and small dosage group (15, 10 g/kg respectively), 15 quails in each group. The control group was given the common diet, and the other groups were given the yeast powder, continuous administration for 28 days. UA, Ins, E2 level and GAPDH activity were detected, and ISI was calculated. Results Compared with control group, UA level of model group during 28 days was significantly higher. Compared with model group, UA level of Cichorii extract groups were significantly lower. Ins and ISI of each group did not change significantly. Compared with control group, E2 level of model group was significantly lower. Compared with model group, E2 levels of Cichorii extract groups were significantly increased. GAPDH level of model group was significantly lower and Cichorii extract groups were significantly increased. Conclusion The decreasing uric acid mechanism of Cichorii extract is related to increasing E2 level leading to the excretion of uric acid and increasing GAPDH indirectly. Moreover, Cichorii extract can decrease UA level by increasing GAPDH activity.关键词
菊苣提取物/胰岛素抵抗/雌二醇/三磷酸甘油醛脱氢酶/鹌鹑Key words
Cichorii extract j insulin resistance/ E2/ GAPDH/ quails分类
医药卫生引用本文复制引用
杨红莲,张冰,刘小青,林志健..菊苣提取物对雌性鹌鹑高尿酸血症模型胰岛素抵抗和雌二醇、三磷酸甘油醛脱氢酶的影响[J].中国中医药信息杂志,2011,18(11):39-40,43,3.基金项目
国家自然科学基金(30472282) （30472282）
北京市自然科学基金(7052036) （7052036）
