中国中医药信息杂志2011，Vol.18Issue(11)：46-48,3.DOI:10.3969/j.issn.1005-5304.2011.11.018
补阳还五汤对脊髓损伤大鼠脊髓组织血小板活化因子含量的影响
Effect of Buyang Huanwu Decoction on the Content of Platelet Activating Factor in Spinal Cord Tissue of Rats with Spinal Cord Injury
摘要
Abstract
Objective To explore the influence of Buyang Huanwu Decoction on the content of platelet activating factor (PAF) in spinal cord tissue of the rats with spinal cord injury (SCI). Methods Wistar rats in SPF grade were used for medium SCI models formation. The SCI models were built based on modified Allen's method. According to modified Tarlov criteria, 48 rats with stable condition, whose hind limb motor function evaluation scored 2-3 points, were randomly divided into model blank group, Buyang Huanwu Decoction group and Ginaton group. Rats were treated for 2 weeks with Buyang Huanwu Decoction at a dose of 40 g/(kg ? BW) in Buyang Huanwu Decoction group, Ginaton at a dose of 45.5 mg/(kg ? BW) in Ginaton group, same volume of distilled water in normal group and model blank group. At the end of the treatment, the content of PAF in the spinal cord tissue of rats was detected by enzyme linked immunosorbent assay (ELISA). Results There was statistical difference between Buyang Huanwu Decoction group and model blank group, normal group (P<0.05), but no statistical difference compared with Ginaton group (P>0.05). Both Buyang Huanwu Decoction and Ginaton could decrease the content of PAF in the spinal cord tissue of rats with SCI, and the difference between Buyang Huanwu Decoction group and model blank group was statistically significant (P<0.01), and Buyang Huanwu Decoction was more efficient than Ginaton with statistical difference (P<0.01). Conclusion Buyang Huanwu Decoction can improve the hind limb motor function and inhibit weight loss of rats with SCI, which may be related to the decrease of the PAF content and the relief of the secondary injury of PAF on spinal cord tissue.关键词
补阳还五汤/脊髓损伤/脊髓组织/血小板活化因子/大鼠Key words
Buyang Huanwu Decoction/ spinal cord injury/ spinal cord tissue/ platele activating factor/ rats分类
医药卫生引用本文复制引用
张继平,王志彬,林爱华,李蜀光,文凤妮,姚晖..补阳还五汤对脊髓损伤大鼠脊髓组织血小板活化因子含量的影响[J].中国中医药信息杂志,2011,18(11):46-48,3.基金项目
广东省科技厅科技攻关项目(2004B36001009) （2004B36001009）
