中国药房2011，Vol.22Issue(44)：4169-4170,2.
奈达铂联合氟尿嘧啶治疗晚期鼻咽癌的临床观察
Clinical Observation of Nedaplatin Combined with Fluorouracil in the Treatment of Advanced Nasopharyngeal Carcinoma
徐倩 1孙东斌2
作者信息
- 1. 胜利油田中心医院药剂科,东营市257034
- 2. 胜利油田中心医院肿瘤科,东营市257034
- 折叠
摘要
Abstract
OBJECTIVE: To observe short-term efficacy and safety of nedaplatin (NDP) combined with fluorouracil (5-FU) in the treatment of advanced nasopharyngeal carcinoma. METHODS: 42 cases of advanced nasopharyngeal carcinoma were randomly divided into treatment group and control groups equally in our hospital from 2005 to 2011. Treatment group was given NDP 80~ 100 mg·m-2, iv. Gtt., d1; 5-FU 600 mg·m-2, d1-5. Control group was given CDDP 30 mg·m-2,iv.gtt., d,1-3,5-FU 600 mg·m-2'.d1-5. A treatment course lasted for 3 weeks. After 2 periods, short-term efficacy and adverse drug reaction were evaluated. RESULTS: The total effective rates of 2 groups were 61.90% and 38.10%, there was statistical significance (P<0.05). ADR of digestive tract and liver and kidney toxicity in treatment group was lighter than control group, there was statistical significance (.P<0.05). CONCLUSION: The short-term efficacy and safety of NDP combined with 5-FU have sound short-term efficacy and safety in the treatment of advanced nasopharyngeal carcinoma.关键词
奈达铂/顺铂/晚期鼻咽癌Key words
Nedaplatin/ Cisplatin/ Advanced nasopharyngeal carcinoma分类
医药卫生引用本文复制引用
徐倩,孙东斌..奈达铂联合氟尿嘧啶治疗晚期鼻咽癌的临床观察[J].中国药房,2011,22(44):4169-4170,2.
