山东医药2011，Vol.51Issue(44)：4-6,3.
c-Src在RANKL诱导的乳腺癌MDA-MB-231细胞迁移中的作用
Role of c-Src in RANKL-induced breast cancer cell MDA-MB-231 migration
摘要
Abstract
Objective To explore the role of c-Src in regulation of MDA-MB-231 breast cancer cells migration by RANKL. Methods Trans well technique was used to assay the migration of breast cancer cells MDA-MB-231. The expression of RANK, phospho-Src, c-Src and actin were measured by Western blot method. Results RANK was expressed in human breast cancer cell line MDA-MB-231, and RANKL increased significantly the migration of MDA-MB-231 cells. The decoy receptor OPG significantly blocked the increased migration. C-Src was activated after RANKL stimulated, the c-Src inhibitor PP2 inhibited obviously RANKL-induced MDA-MB-231 cells migration. Conclusion c-Src was involved in RANKL-induced breast cancer MDA-MB-231 cell migration.关键词
c-Src/核因子-kB受体活化因子配体/乳腺肿瘤/迁移Key words
c-Src/RANKL/breast cancer/migration分类
医药卫生引用本文复制引用
张凌云,曲秀娟,刘云鹏,侯科佐..c-Src在RANKL诱导的乳腺癌MDA-MB-231细胞迁移中的作用[J].山东医药,2011,51(44):4-6,3.基金项目
国家青年科学基金资助项目(30700807) （30700807）
辽宁省教育厅重点实验室项目(2008S246). （2008S246）
