中国普通外科杂志2011，Vol.20Issue(11)：1188-1191,4.
戈舍瑞林对绝经前乳腺癌患者化疗期间卵巢功能的保护
Protective effect of goserelin on ovarian function during chemotherapy of premenopausal women with breast cancer
贾国丛 1赵晓燕 1任胜楠1
作者信息
- 1. 郑州大学第三附属医院乳腺科,河南郑州450052
- 折叠
摘要
Abstract
Objective To assess the protective effect of goserelin on the ovarian function of premenopausal patients with breast cancer during chemotherapy. Methods The clinical data of premenopausal patients with breast cancer treated in the recent two-year period were retrospectively analyzed. The patients were divided into study group ( goserelin plus conventional chemotherapy) and control group ( conventional chemotherapy) with 40 cases in each group. The menstrual status and the hormone levels during chemotherapy and first year follow-up after chemotherapy between the two groups were observed. Results All the 80 patients completed their chemotherapy treatment and all of them developed menstrual disorders. The menstrual recovery rate of the observation group and the control group was 85% and 55% , respectively, and the difference between the two groups had statistical significance ( P = 0. 007 ) . In the observation group, the serum oestradiol ( E2 ) decreased to postmenopausal level, and the serum levels of follicle stimulating hormone ( FSH ) were also significantly decreased during combination treatment ( goserelin plus conventional chemotherapy ) . In the control group, the E2 levels decreased gradually while FSH and LH level increased significantly during chemotherapy. Conclusions Goserelin administration during chemotherapy can effectively prevent the ovarian function injury caused by chemotherapy, and can help maintain normal menstruation and fertility for the young and middle-aged patients.关键词
乳腺肿瘤/戈舍瑞林/卵巢功能/化学疗法,辅助Key words
Breast Neoplasms/ Goserelin / Ovaiy Function/ Chemotherapy , Adjuvant分类
医药卫生引用本文复制引用
贾国丛,赵晓燕,任胜楠..戈舍瑞林对绝经前乳腺癌患者化疗期间卵巢功能的保护[J].中国普通外科杂志,2011,20(11):1188-1191,4.
